Just had a call from Karen Fordham. Looks like my biggest fear may have come true. I've waited so long for the funding, I might have waited too long.
My blood test results are back already. Nice of Karen to call so late in the day, it was 7:30 pm and she was still working!
Results were:
E2: 152 ... Fine
FSH: 6 ... Fine (needs to be less than 9)
AMH: 2 ... NOT fine, ideally should be 10
Seems this could be a potential show stopper. I feel a bit sick, just the injustice of it. Still, they haven't said no, yet. The biggest problem is that the PGD test takes months, possibly a year, so if my level is low now, it's likely to be even lower at treatment start time. There's a meeting next Tuesday evening, my case will be discussed then to see if there's anything can be done.
So now we wait a few days, feeling deflated, but trying not to give up hope.
Showing posts with label E2. Show all posts
Showing posts with label E2. Show all posts
Thursday, 1 December 2011
Monday, 28 November 2011
I have follicles and he has working bollickles!!
Hubby laughed when I said that. I guess a sense of humour is going to be vital through this :)
Today I was seen by Lynn (doctor) and Nathalie (nurse) and I had an ORT (Ovarian Reserve Test). The description on the CRGH website is:
"The ORT (Ovarian Reserve Test) is performed between days 2-5 of the period. It involves a transvaginal scan and baseline blood hormone profile (E2, FSH and AMH)."
So they tell you what it is, but not what they are looking for or why they do the test. The scan (see blog dated 4th November 2011) was to count the follicles. I had five one side and four the other. This is a good number, a relief given my age. The number of follicles is a good indicator of how many eggs a woman has left (remember we're born with all our eggs, once they're gone, they're gone!)
While I was having my scan, the nurse said "I'm just going to take some blood while you are having that done". Hang on a minute! One thing at a time, I'm busy! Oh, I don't think I have a choice in this. I guess might as well get it all over at the same time! I'm a woman, I can multitask. There was of course the advantage that I was laying down, no chance of passing out :)
I was reading a CRGH brochure that I'd kept from a visit about 3 years ago. It describes how they used to just test the FSH hormone levels, but that it was possible that a woman can still have normal FSH levels even though their egg reserve is low. Hence they now do the scan and use the number of follicles as an additional indicator.
Blood test over and done with very quickly, and I was told to phone Karen next Tuesday as the results will take about 1 week.
I found a useful diagram:
I also found a few videos, I'll evaluate them and post a link to the ones I think are best.
More detailed information for those who want to know ......
First day of period flow is counted as day one.
A follicle is an anatomical structure in which the primary oocyte (mature egg) develops. Typically around 20 follicles mature each month and only a single follicle is ovulated (an oocyte is released). The rest undergo atresia. That single dominant follicle becomes a corpus luteum following ovulation.
The blood test checks for three hormone levels:
AMH (Anti-Mullerian Hormone) is a hormone that is produced by the ovaries and is strongly correlated with the egg follicle pool. This hormone does not fluctuate month to month like other hormones, and is a strong predictor of ovarian reserve.
E2 - Estradiol (also known as Oestradiol). From Wikipedia: estradiol acts as a growth hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary. During the menstrual cycle, estradiol produced by the growing follicle triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation
FSH - Follicle Stimulating Hormone, produced by the pituitary gland and directly stimulates the ovaries to recruit and support ovarian follicles, each containing one egg. The hypothalamus adjusts the production of FSH depending upon the levels of other hormones such as estrogen.
Healthy day 3 FSH levels are generally less than 10. Values of 10 to 18 are generally intermediate and are sometimes associated with lower fertility and higher miscarriage rates. Pregnancies are rare and miscarriages increase with high FSH values more than 18. This hormone level needs to be considered along with the E2 level, to check that the FSH level was tested whilst the E2 level was low (which it will be on days 3/4). A high FSH level can be an indicator of low ovarian reserve in older women, less so in younger woman, hence the additional Antral follicle count.
Today I was seen by Lynn (doctor) and Nathalie (nurse) and I had an ORT (Ovarian Reserve Test). The description on the CRGH website is:
"The ORT (Ovarian Reserve Test) is performed between days 2-5 of the period. It involves a transvaginal scan and baseline blood hormone profile (E2, FSH and AMH)."
So they tell you what it is, but not what they are looking for or why they do the test. The scan (see blog dated 4th November 2011) was to count the follicles. I had five one side and four the other. This is a good number, a relief given my age. The number of follicles is a good indicator of how many eggs a woman has left (remember we're born with all our eggs, once they're gone, they're gone!)
While I was having my scan, the nurse said "I'm just going to take some blood while you are having that done". Hang on a minute! One thing at a time, I'm busy! Oh, I don't think I have a choice in this. I guess might as well get it all over at the same time! I'm a woman, I can multitask. There was of course the advantage that I was laying down, no chance of passing out :)
I was reading a CRGH brochure that I'd kept from a visit about 3 years ago. It describes how they used to just test the FSH hormone levels, but that it was possible that a woman can still have normal FSH levels even though their egg reserve is low. Hence they now do the scan and use the number of follicles as an additional indicator.
Blood test over and done with very quickly, and I was told to phone Karen next Tuesday as the results will take about 1 week.
I found a useful diagram:
I also found a few videos, I'll evaluate them and post a link to the ones I think are best.
More detailed information for those who want to know ......
First day of period flow is counted as day one.
A follicle is an anatomical structure in which the primary oocyte (mature egg) develops. Typically around 20 follicles mature each month and only a single follicle is ovulated (an oocyte is released). The rest undergo atresia. That single dominant follicle becomes a corpus luteum following ovulation.
The blood test checks for three hormone levels:
AMH (Anti-Mullerian Hormone) is a hormone that is produced by the ovaries and is strongly correlated with the egg follicle pool. This hormone does not fluctuate month to month like other hormones, and is a strong predictor of ovarian reserve.
E2 - Estradiol (also known as Oestradiol). From Wikipedia: estradiol acts as a growth hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary. During the menstrual cycle, estradiol produced by the growing follicle triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation
FSH - Follicle Stimulating Hormone, produced by the pituitary gland and directly stimulates the ovaries to recruit and support ovarian follicles, each containing one egg. The hypothalamus adjusts the production of FSH depending upon the levels of other hormones such as estrogen.
Healthy day 3 FSH levels are generally less than 10. Values of 10 to 18 are generally intermediate and are sometimes associated with lower fertility and higher miscarriage rates. Pregnancies are rare and miscarriages increase with high FSH values more than 18. This hormone level needs to be considered along with the E2 level, to check that the FSH level was tested whilst the E2 level was low (which it will be on days 3/4). A high FSH level can be an indicator of low ovarian reserve in older women, less so in younger woman, hence the additional Antral follicle count.
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