I phoned and spoke to a nurse today, I seem to be reacting badly to the Crinone Gel. I've probably put up with the discomfort longer than I should have done. Looks like it's a side effect rather than something that is expected. The clinic faxed a prescription of an alternative Progesterone drug (Cyclogest) to my local pharmacy which I picked up to start using this evening. I hope the soreness wears off quickly. Very unpleasant!!
As we drove away from the pharmacy we then got the all important phonecall....
We have FIVE Embryos from our 13 which do not have Treacher Collins Syndrome. Hmmm so much for 50-50 odds, but hey, what a result! I was so scared the call would tell us they all had it. There were tears of joy, but got myself under control very quickly after Hubby reminded me there's still a heck of a hill to climb yet!
We have a chance!! ET tomorrow 10:30
A journey through Preimplantation Genetic Diagnosis and IVF in an attempt to prevent passing on Treacher Collins Syndrome
Friday, 28 September 2012
Thursday, 27 September 2012
Biopsy Day
We got a call yesterday to say we had 4 top quality and 3 good quality!
Today we had some good news, given that we are against the odds because we can lose embryos at each stage, we had our 7 'frosties' thawed, and only 1 has not survived. So add this to our 7 fresh ones, we have 13 to be biopsied.
I was so pleased when they told me that they were able to biopsy all 13 embryos, and all had survived. So tomorrow is the big day for PGD testing. Should hear Saturday, there's a small chance we might hear late in the day Friday.
Tomorrow is going to be tough!!!
Hubby knew I was feeling a bit 'lost' yesterday. Its a weird feeling, waiting for phonecalls with such important news and knowing the fate of your little embryos are in the hands of others. He arrived home with a lovely bunch of roses. :)
Today we had some good news, given that we are against the odds because we can lose embryos at each stage, we had our 7 'frosties' thawed, and only 1 has not survived. So add this to our 7 fresh ones, we have 13 to be biopsied.
I was so pleased when they told me that they were able to biopsy all 13 embryos, and all had survived. So tomorrow is the big day for PGD testing. Should hear Saturday, there's a small chance we might hear late in the day Friday.
Tomorrow is going to be tough!!!
Hubby knew I was feeling a bit 'lost' yesterday. Its a weird feeling, waiting for phonecalls with such important news and knowing the fate of your little embryos are in the hands of others. He arrived home with a lovely bunch of roses. :)
Tuesday, 25 September 2012
Cycle 3 - Fertilisation results
Of my 12 eggs:
1 wasn't fully developed
1 didn't not survive the ICSI injection
7 fertilised !!
3 have not fertilised
We will get a call tomorrow to tell us the quality, the biopsies will be done on Thursday along with our frozen ones (depending how how survive thawing, there will be up to 7 of those)
The PGD test will be done Friday, we are likely to find out the results on Saturday.
I'm so pleased we have a good number this cycle, as it helps our odds, and also as there is a risk that 3 day old embryos will not survive thawing (15%) it's better to have out larger number in this last fresh cycle.
Today I started the tablets (Progynova) and Clexane injections. Oh well at least my poor tummy had a break for 2 days !!
1 wasn't fully developed
1 didn't not survive the ICSI injection
7 fertilised !!
3 have not fertilised
We will get a call tomorrow to tell us the quality, the biopsies will be done on Thursday along with our frozen ones (depending how how survive thawing, there will be up to 7 of those)
The PGD test will be done Friday, we are likely to find out the results on Saturday.
I'm so pleased we have a good number this cycle, as it helps our odds, and also as there is a risk that 3 day old embryos will not survive thawing (15%) it's better to have out larger number in this last fresh cycle.
Today I started the tablets (Progynova) and Clexane injections. Oh well at least my poor tummy had a break for 2 days !!
Labels:
Biopsy,
EC,
Egg Collection,
Fertilisation,
Frozen,
PGD
Monday, 24 September 2012
Egg Collection 24th Sept
I'm gobsmacked! They collected 12 eggs! Turned out there were 12 follicles, and all of them contained an egg. This good number has to improve our odds, so I'm really pleased. Of course we now need to see how many fertilise. Last time it was 50%. Hoping better this time. But at least of it is 50%, then we'll still have the 10 we need.
This Egg collection was fine, like the second one. Went to theatre a little early. Was back in ward about 30 mins later, and walking out just over an hour after that after a much welcomed cuppa and custard creme biscuits !!
Another drug regime now starts ....
Waiting for that all important phonecall ...
This Egg collection was fine, like the second one. Went to theatre a little early. Was back in ward about 30 mins later, and walking out just over an hour after that after a much welcomed cuppa and custard creme biscuits !!
Another drug regime now starts ....
- Crinone Gel (progesterone) morning and night (vaginally - lovely!)
- Progynova (oestrogen) tablet three times a day,
- 75mg Asprin in the evening
- Clexane (blood thinning) injection in the evening.
Waiting for that all important phonecall ...
Friday, 21 September 2012
Cycle 3 - Last scan
We went for our scan and blood test yesterday, and have gained a follicle. We now have 10! I think the sizes are getting close to what they need to do Egg Collection, so they called us in for another scan today. They weren't quite big enough so they've asked us to go in again tomorrow!
I think they then felt sorry for me, and phoned me later saying don't worry about a scan tomorrow, Egg Collection will be Monday regardless. Do Trigger shot 9 PM tomorrow (Saturday) then come in at 9am Monday 24th for Egg Collection.
Pleased with that :)
I think they then felt sorry for me, and phoned me later saying don't worry about a scan tomorrow, Egg Collection will be Monday regardless. Do Trigger shot 9 PM tomorrow (Saturday) then come in at 9am Monday 24th for Egg Collection.
Pleased with that :)
Wednesday, 19 September 2012
Sick!
Felt very nauseous again this morning, and was actually sick twice :-(. Felt fine for the rest of the day though. I am on a different drug this time, but would not have thought it would be that different. No such side effects in previous cycles.
Tuesday, 18 September 2012
Better news
Scan today showed 9 follicles. Seems the 'Dinky' ones caught up. The doc remembered the word! :-) Very pleased about this. We really need as many as possible. Looking back at last cycle we had 8 collected, only 4 fertilised.
I laid out my drugs ready to do. This lot is just for ONE evening!!
I laid out my drugs ready to do. This lot is just for ONE evening!!
Sunday, 16 September 2012
Cycle 3 - First Scan
First scan today since baseline scan. I felt extremely nauseous this morning, about 15 minutes before we were due to leave. Luckily it eased off else I'd not have been able to leave on time!
Scan showed 5 follicles. 3 on left, 2 on right. I was disappointed, really hoped for more, especially as often the number of eggs retrieved is lower then the follicle count. We need as many as possible!!
Hubby taught the doctor a new word ... "Dinky"! She thought it was great and hadn't heard of it before :)
Still, think positive, early days yet!
Scan showed 5 follicles. 3 on left, 2 on right. I was disappointed, really hoped for more, especially as often the number of eggs retrieved is lower then the follicle count. We need as many as possible!!
Hubby taught the doctor a new word ... "Dinky"! She thought it was great and hadn't heard of it before :)
Still, think positive, early days yet!
Tuesday, 11 September 2012
Cycle 3 begins
As I predicted, AF arrived yesterday so I had my baseline scan today. All is ok, and I start the drugs tonight. Protocol slightly different this time. Merional instead of Menopur, and instead of 225 & 225 split, I'll be taking 300 Merional and 150 Gonal F
Cetrotide will start later, at least after Cycle Day 7 and Zomacton growth hormone starts tonight and then alternate days.
The Strange thing about Merional is it comes as a powder vial and solution (just like menopur) but rather than mix up a batch and use it over 2-3 days, I need to mix 4 just to get enough to make up my 300 because it comes in such small quantities.
And we're off ...!
Cetrotide will start later, at least after Cycle Day 7 and Zomacton growth hormone starts tonight and then alternate days.
The Strange thing about Merional is it comes as a powder vial and solution (just like menopur) but rather than mix up a batch and use it over 2-3 days, I need to mix 4 just to get enough to make up my 300 because it comes in such small quantities.
And we're off ...!
Monday, 27 August 2012
Dummy transfer and 3D SIS
This was one appointment I wasn't looking forward to. Supposed to be the most invasive, "uncomfortable" procedure in IVF.
3D SIS:
3D saline infusion sonography (SIS) is done in the CRGH and involves an ultrasound scan whilst a small amount of saline is injected into the womb. Using the scan machine, the outline of the womb can be determined. A hysteroscopy involves putting a small scope into the womb to see if it is normal.
I was pleased that we were seen fairly close to our appointment time and not left to get anxious. I was told to turn up with a full bladder. I'd had a tea at home, some water, a coffee at the station, a glass of water with lunch, and a glass of water in the waiting room. I'd not been to the toilet since 10am. A quick scan revealed that my bladder "wasn't very full". Blimey, how much more should I have had!? It was good enough and they went ahead with the dummy embryo transfer. This was ok, a little uncomfortable, but only because they use a speculum. So it's no worse than a smear test.
I was then told to go to the toilet, and was back for the second part: 3D SIS. The doctor warned me I will probably experience some pain. I did! It was like bad period pain, but was over quite quickly. The pain only occurred at the end as the jelly like saline was pumped in. The pain is caused by the pressure. The scan revealed everything was ok. No issues or concerns. <relief>
I was given some antibiotics and told not to bath or swim, I was also given Norethisterone ready to take on 23rd August and told all the other drugs would be sent by Healthcare at Home as usual.
3D SIS:
3D saline infusion sonography (SIS) is done in the CRGH and involves an ultrasound scan whilst a small amount of saline is injected into the womb. Using the scan machine, the outline of the womb can be determined. A hysteroscopy involves putting a small scope into the womb to see if it is normal.
I was pleased that we were seen fairly close to our appointment time and not left to get anxious. I was told to turn up with a full bladder. I'd had a tea at home, some water, a coffee at the station, a glass of water with lunch, and a glass of water in the waiting room. I'd not been to the toilet since 10am. A quick scan revealed that my bladder "wasn't very full". Blimey, how much more should I have had!? It was good enough and they went ahead with the dummy embryo transfer. This was ok, a little uncomfortable, but only because they use a speculum. So it's no worse than a smear test.
I was then told to go to the toilet, and was back for the second part: 3D SIS. The doctor warned me I will probably experience some pain. I did! It was like bad period pain, but was over quite quickly. The pain only occurred at the end as the jelly like saline was pumped in. The pain is caused by the pressure. The scan revealed everything was ok. No issues or concerns. <relief>
I was given some antibiotics and told not to bath or swim, I was also given Norethisterone ready to take on 23rd August and told all the other drugs would be sent by Healthcare at Home as usual.
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